THE MIRIAM HOSPITAL

Headquarter of

CORP_53984363

ILLINOIS

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1518482389

2023-05-11

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EVA GREENWOOD

SVP, FINANCE

4014447914

261QR0404X - Cardiac Rehabilitation Clinic/Center

Yes

+1 401-444-6779

4014446912

+1 401-793-5810

UCC-3 TERMINATION

202531820430

2025-04-03

TerminationSecuredParty

THE MIRIAM HOSPITAL

Debtor(s)

UCC-3 CONTINUATION

202431360090

2024-11-25

Continuation

THE MIRIAM HOSPITAL

Debtor(s)

EMMA PENDLETON BRADLEY HOSPITAL

Debtor(s)

LIFESPAN CORPORATION

Debtor(s)

RHODE ISLAND HOSPITAL

Debtor(s)

UCC-3 CONTINUATION

202431303060

2024-11-08

Continuation

THE MIRIAM HOSPITAL

Debtor(s)

INTUITIVE SURGICAL, INC.

Secured Parties

36C24124P0751

View Award on USAspending website

AWARD

PURCHASE ORDER

Department of Veterans Affairs

2024-08-09

17850.00

17850.00

17850.00

QUALITATIVE SCIENCE METHODS TRAINING PROGRAM

611310: COLLEGES, UNIVERSITIES, AND PROFESSIONAL SCHOOLS

U004: EDUCATION/TRAINING- SCIENTIFIC/MANAGEMENT

36C24123P0862

View Award on USAspending website

AWARD

PURCHASE ORDER

Department of Veterans Affairs

2023-07-01

12600.00

12600.00

12600.00

QSMTP TRAINING

611310: COLLEGES, UNIVERSITIES, AND PROFESSIONAL SCHOOLS

U008: EDUCATION/TRAINING- TRAINING/CURRICULUM DEVELOPMENT

W912LD23F0013

View Award on USAspending website

AWARD

BPA CALL

Department of Defense

2023-04-30

13754.70

13754.70

13754.70

FY22 APRIL MIRIAM LAB CHARGES

621511: MEDICAL LABORATORIES

Q301: MEDICAL- LABORATORY TESTING

2024-09-20

View on USAspending

Department of Health and Human Services

A MULTIDISCIPLINARY APPROACH TO INTEGRATE HIV PREVENTION SERVICES INTO CLINICAL CARE SETTINGS FOR PEOPLE WITH OPIOID USE DISORDER - PROJECT SUMMARY OPIOID USE CONTINUES TO BE A PUBLIC HEALTH CRISIS IN THE UNITED STATES (US). AN ESTIMATED 2.7 MILLION PEOPLE HAD OPIOID USE DISORDER (OUD) WITH OVER 107,000 OVERDOSE DEATHS IN 2022 IN THE US. OUD IS ALSO A MAJOR RISK FACTOR FOR HIV INFECTION DUE TO INJECTION AND HIGH-RISK SEXUAL BEHAVIORS. DESPITE THE HIGHER RISK OF HIV, OUD PATIENTS HAVE HAD VERY LIMITED ENGAGEMENT WITH HIV PREVENTION SERVICES, INCLUDING HIV SCREENING, HIV PRE- EXPOSURE PROPHYLAXIS (PREP), AND MEDICATION FOR OUD (MOUD) SERVICES, WHICH ARE HIGHLY EFFECTIVE IN PREVENTING HIV INFECTION. NOVEL APPROACHES ARE NEEDED TO EXPLORE HOW TO ENGAGE PEOPLE WITH OUD IN HIV PREVENTION SERVICES WITH THE LONG-TERM GOAL OF REDUCING HIV INCIDENCE. THE INTEGRATION OF HIV PREVENTION SERVICES INTO CARE SETTING (E.G. EMERGENCY DEPARTMENTS, PRIMARY CARE, MENTAL HEALTH CLINICS, AND SUBSTANCE TREATMENT CENTERS) WHERE PEOPLE WITH OUD ALREADY SEEK CARE IS PROMISING. AS THE INTEGRATION OF HIV PREVENTION SERVICES INTO CARE SETTINGS IS COMPLICATED DUE TO THE INDIVIDUAL-, SOCIAL- AND STRUCTURAL-LEVEL BARRIERS, WE WILL USE INNOVATION AND MULTIDISCIPLINARY APPROACHES TO ACHIEVE THIS GOAL. IN THIS PROPOSAL, WE WILL CONDUCT A SYSTEMATIC ASSESSMENT OF HEALTHCARE UTILIZATION IN GENERAL, HIV PREVENTION SERVICES, AND MOUD USING THE ALL PAYERS CLAIMS DATABASE (APCD) AND STATE EMERGENCY DEPARTMENT DATABASE (SEDD) (SPECIFIC AIM (SA) 1), USE THE EVIDENCE-BASED QUALITY IMPROVEMENT (EBQI) - A COLLABORATIVE STAKEHOLDER-GUIDED INTERVENTION/STRATEGY DEVELOPMENT PROCESS TO DETERMINE THE OPTIMAL CARE SETTING AND IDENTIFY IMPLEMENTATION STRATEGIES OF INTEGRATING HIV PREVENTION SERVICES AND MOUD (SA 2), AND THEN TEST THEIR EFFECTS ON REDUCING HIV INCIDENCE AT THE POPULATION LEVEL USING AGENT-BASED MODELING (SA3). THIS INNOVATIVE STUDY WILL IDENTIFY CARE SETTINGS TO MAXIMUM HIV PREVENTION EFFORTS, TEST MULTIPLE PROMISING IMPLEMENTATION STRATEGIES, AND IDENTIFY THE MOST EFFECTIVE IMPLEMENTATION STRATEGY, WHICH IS READY FOR REAL-WORLD IMPLEMENTATION.

596306.00

0.00

0.00

2024-09-12

View on USAspending

Department of Health and Human Services

HIV DRUG RESISTANCE IN THE NEW ANTIRETROVIRAL THERAPY ERA IN KENYA - HIV DRUG RESISTANCE IN THE NEW ART ERA IN KENYA RAMI KANTOR, MD SUMMARY SINCE THE EMERGENCE OF RESISTANCE TO ZIDOVUDINE IN THE LATE 1980’S, WE HAVE BEEN IN A RACE: AN HIV DRUG IS DEVELOPED AND USED, FOLLOWED BY THE INEVITABLE EMERGENCE OF VIRAL RESISTANCE TO IT, ANOTHER DRUG IS DEVELOPED AND USED, AND SO ON. THIS LARGELY RESISTANCE-DRIVEN PROCESS HAS INFORMED ANTIRETROVIRAL DRUG DEVELOPMENT SINCE ITS INCEPTION. HOWEVER, TREATMENT MONITORING, INCLUDING DRUG RESISTANCE TESTING AND AT TIMES VIRAL LOAD TESTING, ARE LIMITED IN RESOURCE LIMITED SETTINGS, WHERE HIV BURDEN IS GREATEST, CREATING THE GLOBAL PARADOX: WE TEST FOR AND KNOW LESS ABOUT HIV DRUG RESISTANCE IN LOCATIONS WHERE OUR UNDERSTANDING OF IT IS MOST CRUCIAL. SUCH SETTINGS MAY BE MORE PRONE FOR RESISTANCE DUE TO RESTRICTED MONITORING IN CLINICAL CARE, HIGHER TREATMENT FAILURE THRESHOLDS, LIMITED AVAILABILITY OF ADVANCED MEDICATIONS AND FORMULATIONS, CIRCULATING DIVERSE HIV-1 SUBTYPES, AND SPECIAL CIRCUMSTANCES LIKE HIV-TB COINFECTION. SUCH SITUATIONS MIGHT FURTHER ENHANCE THE RISK TO DEVELOP RESISTANCE AND EXACERBATE THE COMPLEXITY OF ADDRESSING IT. THIS PARADOX IS EVEN GREATER NOW THAT WE ARE IN THE NEW GLOBAL ANTIRETROVIRAL THERAPY (ART) ERA. REMARKABLE PROGRESS IN ANTIRETROVIRALS LIKE DOLUTEGRAVIR (DTG), WITH ENHANCED EFFICACY, REDUCED TOXICITY, HIGH BARRIER TO RESISTANCE, AND IMPORTANTLY, GLOBAL ACCESSIBILITY, ALL INSTILL A PROFOUND CONFIDENCE, SUGGESTING THAT WE MAY HAVE ACHIEVED A PIVOTAL MILESTONE IN THE ONGOING RACE AGAINST HIV. HOWEVER, THE WIDESPREAD UTILIZATION OF DTG IN ALL LINES OF ART, ESPECIALLY IN SETTINGS WITH IMPERFECT MONITORING AND LIMITED MEDICATION AVAILABILITY, RAISES CONCERNS ABOUT CONTINUING THE DRUG RESISTANCE RACE. EMERGING DATA CONFIRM THESE CONCERNS AND HIGHLIGHT RESEARCH GAPS RELATED TO RESISTANCE DEVELOPMENT TO CURRENT ERA DRUGS AND THEIR MAGNITUDE AND CONSEQUENCES. THIS PROPOSAL IS DESIGNED TO ADDRESS THESE GAPS. LEVERAGING OUR LONG-STANDING NORTH- SOUTH COLLABORATION, WE PROPOSE TO COMPREHENSIVELY AND PROSPECTIVELY INVESTIGATE THE EXTENT AND IMPACT OF TRANSMITTED AND ACQUIRED RESISTANCE IN A LARGE HIV CARE PROGRAM IN KENYA, ONE OF THE EARLIER COUNTRIES TO ENTER THE NEW ART ERA IN 2017. WE HYPOTHESIZE THAT THE SCALE-UP OF DTG-BASED REGIMENS ACROSS ALL LINES OF TREATMENT IN RESOURCE LIMITED SETTINGS IS LEADING TO A GRADUAL ESCALATION OF DRUG RESISTANCE OVER TIME, IMPACTING CARE. TO ADDRESS THIS HYPOTHESIS, WE WILL ENROLL AND PROSPECTIVELY FOLLOW 1,840 KENYAN PERSONS WITH HIV ACROSS THE HIV, ART AND RESISTANCE TIMELINES. WE WILL CHARACTERIZE TRANSMITTED RESISTANCE (AIM 1) AND INVESTIGATE ACQUIRED RESISTANCE (AIM 2) OF 1ST-LINE DTG-BASED ART (AIM 2A), 2ND-LINE ART (AIM 2B), BEYOND 2ND-LINE ART (AIM 2C), AND SPECIAL POPULATIONS (AIM 3). OUR UNDERSTANDING OF RESISTANCE DEVELOPMENT IN THE NEW ART ERA IS LIMITED, YET CRUCIAL TO ENSURE ITS SUSTAINABLE SUCCESS. THIS TIMELY PROPOSAL WILL GENERATE HYPOTHESIS-DRIVEN DATA TO ADDRESS EXISTING GAPS AND INFORM PATIENT CARE TOWARDS ENDING THE HIV EPIDEMIC. WE EXPECT TO HAVE A HIGH AND DIRECT IMPACT ON GUIDING FUTURE ART STRATEGIES TO MINIMIZE RESISTANCE. THE NEW ART ERA HAS BEEN ROLLED OUT FOR ~5 YEARS, PROVIDING A UNIQUE OPPORTUNITY TO CONDUCT THIS RESEARCH. THE RIGHT TIME TO COMPREHENSIVELY INVESTIGATE RESISTANCE IN THE NEW ART ERA IS NOW, TO ENSURE THAT WE DON’T LOSE THE RACE, IN KENYA AND BEYOND.

645900.00

0.00

0.00

2024-08-06

View on USAspending

Department of Health and Human Services

AN APPLICATION OF SMART METHODOLOGY TO OPTIMIZE AN INTERVENTION TO MAINTAIN IMPROVEMENTS IN HEALTH BEHAVIORS IN UNDER-RESOURCED PATIENTS AFTER PHASE II CARDIAC REHABILITATION - PROJECT SUMMARY/ABSTRACT CARDIOVASCULAR DISEASE (CVD) IS THE LEADING CAUSE OF DEATH IN THE UNITED STATES. CARDIAC REHABILITATION (CR) IS AN EVIDENCE-BASED, COST-EFFECTIVE, AND WIDELY AVAILABLE MULTIDISCIPLINARY PROGRAM THAT COMBINES SUPERVISED EXERCISE WITH PSYCHOEDUCATION ON HEALTH BEHAVIOR CHANGE AIMED AT IMPROVING OVERALL HEALTH AND REDUCING CARDIOVASCULAR RISK IN INDIVIDUALS WITH ESTABLISHED CVD. HOWEVER, UNDER-RESOURCED AND UNDERSERVED CVD PATIENTS (E.G., WOMEN, RACIAL AND ETHNIC MINORITIES, LOW SOCIOECONOMIC STATUS, DISABLED) ARE LESS LIKELY TO MAINTAIN THEIR ADHERENCE TO KEY CARDIOPROTECTIVE BEHAVIORS (WEIGHT MANAGEMENT, PHYSICAL ACTIVITY [PA], AND MEDICATION ADHERENCE) AFTER CR AND ARE UNDER-REPRESENTED IN POST-CR RESEARCH; THESE FACTORS COMBINED INCREASE THE HEALTH DISPARITIES IN CVD CARE THAT THESE SUB-POPULATIONS EXPERIENCE, ESPECIALLY SINCE MANY CANNOT COMPLETE SELF-PAY PHASE III MAINTENANCE PROGRAMS. IN THE PI’S PREVIOUS WORK, UNDER-RESOURCED AND UNDER-REPRESENTED PATIENTS INDICATED THAT THEY WANT TECHNOLOGY-BASED MAINTENANCE SUPPORT INTERVENTIONS THAT UTILIZE TECHNOLOGY THEY ALREADY OWN, ARE MINIMAL BURDEN, OFFER A FLEXIBLE SCHEDULE, OFFER MORE SUPPORT FOR PATIENT NEEDS WITHOUT OVERWHELMING THEM WITH PROGRAM REQUIREMENTS BEFORE DEMONSTRATING THAT A LOWER LEVEL OF SUPPORT WAS INSUFFICIENT, AND PRODUCE DESIRED RESULTS. PATIENTS FELT RESISTANT TO INITIATING A DEMANDING, TIME- INTENSIVE, OR IN-PERSON MAINTENANCE INTERVENTION IMMEDIATELY FOLLOWING CR. THE PRESENT APPLICATION UTILIZES A SEQUENTIAL, MULTIPLE ASSIGNMENT, RANDOMIZED TRIAL (SMART) DESIGN TO CREATE A STEPPED CARE MODEL THAT ADAPTS TO PATIENT NEEDS AND MINIMIZES PATIENT BURDEN. PARTICIPANTS (N=400) WILL BE RANDOMIZED TO RECEIVE EITHER A LOW-INTENSITY TEXT MESSAGING INTERVENTION OR AN AUTOMATED ONLINE PROGRAM FOR 2 MONTHS AND DETERMINE WHICH PRODUCES SUPERIOR ADHERENCE (AIM 1). FOLLOWING CLASSIFICATION AS INTERVENTION RESPONDERS OR NON- RESPONDERS, RESPONDERS WILL CONTINUE RECEIVING THEIR INITIAL LOW-INTENSITY INTERVENTION. WE WILL THEN DETERMINE WHETHER LOW- OR HIGH-INTENSITY HOME-BASED CR (WITH OR WITHOUT CASE MANAGEMENT) FOR 3 MONTHS PRODUCES BETTER BEHAVIORAL ADHERENCE FOLLOWING FAILURE OF A LOW-INTENSITY INTERVENTION FAILURE (AIM 2). WE WILL THEN FINALIZE THE IDEAL ADAPTIVE INTERVENTION BASED ON AIMS 1 AND 2 RESULTS AND MODERATOR ANALYSES (AIM 3). PATIENTS WILL COMPLETE POST-INTERVENTION ASSESSMENTS AT 6 MONTHS AND EXPLORATORY OUTCOMES ASSESSMENT (DEATH, REHOSPITALIZATION, QUALITY OF LIFE). THIS RESEARCH WILL RESULT IN A STEPPED CARE MODEL FOR UNDER-RESOURCED PATIENTS’ BEHAVIORAL ADHERENCE MAINTENANCE FOLLOWING CR. THIS PROJECT ADVANCES THE SCIENCE OF CVD TREATMENT AND POST-CR CARE, AND IT WILL DIRECTLY IMPACT CVD PATIENT OUTCOMES BY EXTENDING THE BENEFITS OF EVIDENCE-BASED, EFFECTIVE CARE AS WELL AS TARGET HEALTH DISPARITIES AMONG LESS-RESOURCED CVD PATIENTS.

740798.00

0.00

0.00

2024-07-31

View on USAspending

Department of Health and Human Services

COMPARISON OF BEHAVIORALLY-BASED REMOTE APPROACHES TO OPTIMIZE WEIGHT LOSS AND IDENTIFICATION OF FACTORS WHICH CHARACTERIZE TREATMENT RESPONSE - PROJECT SUMMARY IN-PERSON BEHAVIORAL WEIGHT LOSS (WL) PROGRAMS ARE THE GOLD STANDARD OF OBESITY TREATMENT, BUT REMOTE-BASED INTERVENTIONS ARE BECOMING INCREASINGLY UTILIZED AS THEY OVERCOME BARRIERS COMMON TO IN-PERSON PROGRAMS (E.G., GEOGRAPHICAL, TIME, AND TRAVEL CONSTRAINTS) AND REPRESENT A MORE TRANSLATABLE INTERVENTION MODEL. YET, REMOTE WL INTERVENTIONS CAN VARY SUBSTANTIALLY, AND QUESTIONS REMAIN REGARDING WHICH TYPE IS MOST EFFECTIVE AND WHETHER THERE ARE CERTAIN GROUPS OF INDIVIDUALS WHO RESPOND BEST TO ONE TYPE OVER ANOTHER. FOR EXAMPLE, OUR FULLY AUTOMATED, ONLINE PROGRAM PRODUCES A 4.5% WL ON AVERAGE AND ABOUT HALF OF PARTICIPANTS ACHIEVE A WL ≥5%. WHILE THIS LOW-TOUCH INTERVENTION IS EFFECTIVE FOR MANY, OTHERS HAVE LIMITED SUCCESS AND MAY BENEFIT FROM A DIFFERENT TYPE OF REMOTE INTERVENTION (E.G., GROUP-BASED VIDEOCONFERENCE PROGRAM, RESEMBLING IN-PERSON TREATMENT) OR MORE INDIVIDUAL SUPPORT (E.G., VIA COACHING). THIS TRIAL UTILIZES A 2X2 FACTORIAL DESIGN TO COMPARE TWO REMOTE-DELIVERY FORMATS (AUTOMATED ONLINE PROGRAM VS. GROUP-BASED VIDEOCONFERENCE PROGRAM) AND THE ADDED EFFECT OF COACHING (VS. NO COACHING) ON 12-MONTH WL. DIRECT COMPARISONS OF THESE APPROACHES HAVE BEEN LIMITED. FROM A PERSONALIZED MEDICINE PERSPECTIVE, IT IS ALSO IMPORTANT TO UNDERSTAND FOR WHOM EACH REMOTE APPROACH SHOULD BE RECOMMENDED. THUS, AN ADDITIONAL AIM IS TO DEVELOP TWO ALGORITHMS WHICH COULD BE USED TO REFER PATIENTS INTO REMOTE WL PROGRAMS. THE ‘WIDELY-APPLICABLE’ ALGORITHM WILL USE METRICS COMMON TO ELECTRONIC MEDICAL RECORDS (SEX, BMI, AGE, RACE, ETHNICITY), AND THE ‘MORE COMPREHENSIVE’ ALGORITHM WILL FURTHER INCLUDE ADDITIONAL BASELINE CHARACTERISTICS (E.G., EDUCATION, HOUSEHOLD INCOME, HEALTH LITERACY, GROUP PREFERENCE, ETC). PARTICIPANTS WILL BE RANDOMIZED AT BASELINE (OUT OF 4 POSSIBLE COMBINATIONS) AND RECEIVE A 12- MONTH, REMOTE-BASED BEHAVIORAL WL PROGRAM. ALL PROGRAMS INCLUDE DAILY SELF-MONITORING OF DIET, EXERCISE, AND WEIGHT AND THE PROVISION OF AUTOMATED FEEDBACK. THOSE RECEIVING THE ONLINE PROGRAM WILL ALSO BE INSTRUCTED TO VIEW VIDEO LESSONS (24 IN TOTAL, 10-15 MIN EACH) WHICH FOCUS ON BEHAVIORAL STRATEGIES FOR CHANGING DIET AND EXERCISE. INDIVIDUALS RANDOMIZED TO THE VIDEOCONFERENCE PROGRAM WILL PARTICIPATE IN 24 GROUP SESSIONS (1 HOUR EACH) DESIGNED TO MIMIC IN-PERSON TREATMENT AND ALLOW FOR PARTICIPANT INTERACTION VIA LARGE AND SMALL GROUP DISCUSSIONS. COACHING CALLS (10-15 MIN EACH) WILL BE MONTHLY AND FOCUS ON INDIVIDUAL BARRIERS, PROBLEM SOLVING, GOAL SETTING, AND FOSTERING SUPPORT AND ACCOUNTABILITY. ASSESSMENTS WILL OCCUR AT BASELINE, 6 (MID-TREATMENT), 12 (POST-TREATMENT), AND 18 MONTHS (FOLLOWING 6 MONTHS OF NO INTERVENTION). SECONDARY AIMS WILL EXAMINE THE EFFECTS OF DELIVERY FORMAT AND COACHING ON INTERVENTION ENGAGEMENT (E.G., FREQUENCY OF SELF-MONITORING), PSYCHOSOCIAL OUTCOMES (E.G., PERCEIVED SUPPORT, SELF-EFFICACY, AND MOTIVATION), 18-MONTH WL, AND THE COST PER KILOGRAM OF WL (TO EXAMINE WHETHER THE ADDITION OF HUMAN SUPPORT IS COST-EFFECTIVE). STUDY FINDINGS HAVE THE POTENTIAL TO INFORM PATIENT REFERRALS AND INSURANCE COVERAGE DECISIONS FOR REMOTE WL TREATMENT.

631896.00

0.00

0.00

2025-01-15

View on USAspending

Department of Health and Human Services

POSTTRAUMATIC STRESS AND STRESS REACTIVITY AFTER MYOCARDIAL INFARCTION - PROJECT SUMMARY/ABSTRACT IN THE US, AN ADULT SUFFERS A MYOCARDIAL INFARCTION (MI) EVERY 40 SECONDS. OVER 35% OF MI PATIENTS DEVELOP POSTTRAUMATIC STRESS DISORDER (PTSD) SYMPTOMS WITHIN 1 MONTH, INCREASING RISK OF 1-YEAR REHOSPITALIZATION AND MORTALITY IN A DOSE-RESPONSE MANNER. HOWEVER, BIOBEHAVIORAL PATHWAYS WHEREBY PTSD SYMPTOMS LEAD TO REHOSPITALIZATION AND MORTALITY HAVE YET TO BE IDENTIFIED. GIVEN PTSD SYMPTOMS POTENTIATE STRESS REACTIVITY AND PATIENTS SHOW GREATER STRESS REACTIVITY AFTER A MI, STRESS REACTIVITY IS A PROMISING MECHANISM TO STUDY IN THE ASSOCIATION BETWEEN PTSD SYMPTOMS AND PROXIMAL CARDIOVASCULAR HEALTH OUTCOMES SUCH AS AMBULATORY BLOOD PRESSURE (ABP). THE OBJECTIVE OF THIS MENTORED PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT AWARD (K23) IS TO PROVIDE DR. SHARON LEE, THE CANDIDATE, WITH NECESSARY TRAINING TO BECOME AN INDEPENDENT CLINICAL SCIENTIST WITH EXPERTISE IN THE BIOBEHAVIORAL MECHANISMS LINKING PTSD SYMPTOMS AND CARDIOVASCULAR DISEASE RISK. TO PREPARE DR. LEE TO BECOME AN INDEPENDENT INVESTIGATOR BY THE COMPLETION OF THIS AWARD, MENTORED TRAINING WILL ADDRESS FOUR DOMAINS: (1) PSYCHOPHYSIOLOGY OF CARDIOVASCULAR STRESS REACTIVITY, (2) METHODOLOGIES IN ECOLOGICAL MOMENTARY ASSESSMENT AND ABP MONITORING, (3) EPIDEMIOLOGY OF MI AND POST-MI CLINICAL OUTCOMES, AND (4) PROFESSIONAL DEVELOPMENT INTO AN INDEPENDENT CLINICAL SCIENTIST IN CARDIOVASCULAR BEHAVIORAL MEDICINE. THE PROPOSED INTENSIVE LONGITUDINAL STUDY FOCUSES ON THE POTENTIAL MECHANISTIC ROLE OF PSYCHOLOGICAL AND PHYSIOLOGICAL STRESS REACTIVITY IN THE ASSOCIATION BETWEEN PTSD SYMPTOMS AND 24-HOUR ABP IN MI PATIENTS. DR. LEE WILL LEVERAGE ECOLOGICAL MOMENTARY ASSESSMENT INCLUDING ABP MONITORING TO EXAMINE THE ASSOCIATION BETWEEN PTSD SYMPTOMS AND STRESS REACTIVITY (MOMENTARY PERCEIVED STRESS AND ABP REACTIVITY) AS IT UNFOLDS DURING THE 6-MONTH POST-MI ADJUSTMENT PERIOD. DATA COLLECTION WILL OCCUR AT THREE TIME POINTS, EACH CONSISTING OF A GOLD-STANDARD CLINICAL ASSESSMENT OF PTSD SYMPTOMS FOLLOWED BY A 7-DAY ECOLOGICAL MOMENTARY ASSESSMENT WITH A 24-HOUR PERIOD OF ABP MONITORING. THE FOLLOWING SPECIFIC AIMS WILL BE ACHIEVED: (1) TEST THE INTRAINDIVIDUAL ASSOCIATION BETWEEN PTSD SYMPTOMS AND STRESS REACTIVITY AND (2) TEST THE ROLE OF STRESS REACTIVITY IN THE INTRAINDIVIDUAL ASSOCIATION BETWEEN PTSD SYMPTOMS AND 24-HOUR ABP. DR. LEE HAS ASSEMBLED AN EXPERT MENTORSHIP TEAM OF LEADING SCIENTISTS IN THE FIELDS OF CLINICAL PSYCHOLOGY, EXPERIMENTAL MEDICINE, BEHAVIORAL CARDIOLOGY, PREVENTIVE CARDIOLOGY, CARDIOVASCULAR EPIDEMIOLOGY, AND INTENSIVE LONGITUDINAL MODELING. THE MIRIAM HOSPITAL AND ALPERT MEDICAL SCHOOL OF BROWN UNIVERSITY ARE IDEALLY RESOURCED ENVIRONMENTS FOR DR. LEE TO SUCCESSFULLY CARRY OUT THE PROPOSED TRAINING AND STUDY. DR. LEE’S K23 TRAINING PLAN AND PROJECT ALIGN WITH THE NHLBI RESEARCH PRIORITY REGARDING MECHANISMS WHEREBY PSYCHOSOCIAL STRESS CONTRIBUTES TO ISCHEMIC HEART DISEASE PROGRESSION. TO THIS END, DR. LEE WILL EMERGE FROM THIS FIVE-YEAR MENTORED AWARD AS AN INDEPENDENT INVESTIGATOR WHO WILL CONTRIBUTE TO OUR KNOWLEDGE ABOUT STRESS REACTIVITY AS A MODIFIABLE MECHANISM FOR DISRUPTING THE RELATIONSHIP BETWEEN PTSD SYMPTOMS AND POOR CARDIOVASCULAR HEALTH IN MI PATIENTS.

374061.00

0.00

0.00

2022-04-28

Complaint

164 SUMMIT AVE., PROVIDENCE, RI, 02906

Safety

Partial

2010-04-14

Complaint

164 SUMMIT AVENUE, PROVIDENCE, RI, 02906

Health

Partial

View Inspection data on OSHA website

1998-03-18

Complaint

164 SUMMIT AVE., PROVIDENCE, RI, 02906

Health

Partial

View Inspection data on OSHA website

1992-08-14

Referral

164 SUMMIT AVE., PROVIDENCE, RI, 02906

Safety

Partial

View Inspection data on OSHA website

1992-07-27

Complaint

164 SUMMIT AVE., PROVIDENCE, RI, 02906

Health

Complete

View Inspection data on OSHA website

05-0258905

Government Instrumentality, Title-Holding Corporation, Charitable Organization, Agricultural Organization, Board of Trade, Pleasure, Recreational, or Social Club, Fraternal Beneficiary Society, Order or Association, Voluntary Employees' Beneficiary Association (Non-Govt. Emps.), Domestic Fraternal Societies and Associations, Teachers Retirement Fund Assoc., Benevolent Life Insurance Assoc., Burial Association, Credit Union, Mutual Insurance Company or Assoc. Other Than Life or Marine, Corp. Financing Crop Operations, Supplemental Unemployment Compensation Trust or Plan, Employee Funded Pension Trust (Created Before 6/25/59), Post or Organization of War Veterans, Legal Service Organization, Black Lung Trust, Multiemployer Pension Plan, Veterans Assoc. Formed Prior to 1880, Trust Described in Sect. 4049 of ERISA, Title Holding Co. for Pensions, etc., State-Sponsored High Risk Health Insurance Organizations, State-Sponsored Workers' Compensation Reinsurance, ACA 1322 Qualified Nonprofit Health Insurance Issuers, Apostolic and Religious Org. (501(d)), Cooperative Hospital Service Organization (501(e)), Cooperative Service Organization of Operating Educational Organization (501(f)), Child Care Organization (501(k)), Charitable Risk Pool, Qualified State-Sponsored Tuition Program, 4947(a)(1) - Private Foundation (Form 990PF Filer)

1935-01

Type of organization and use of contribution: A public charity. Deductibility Limitation: 50% (60% for cash contributions)

2022-09-07

Terminated

no monetary award

Both plaintiff and defendant demand jury

Medical Malpractice

THE MIRIAM HOSPITAL

Defendant

LEDERBERG

Plaintiff

2019-02-12

Terminated

no monetary award

Plaintiff demands jury

Americans with Disabilities Act - Employment

TRIMBLE

Plaintiff

THE MIRIAM HOSPITAL

Defendant

2010-01-27

Terminated

no monetary award

Plaintiff demands jury

Civil Rights Employment

DIFILIPPO-FISHER

Plaintiff

THE MIRIAM HOSPITAL

Defendant