THE MIRIAM HOSPITAL

Headquarter of

CORP_53984363

ILLINOIS

THE MIRIAM HOSPITAL (IL)

KD5TGBT7AKC9

3FWD3

2025-11-04

LIFESPAN

LIFESPAN

2024-11-05

2003-06-09

3FWD3

Active

Non-Manufacturer

2024-11-05

2029-11-05

2025-11-04

MARY GASBARRO

1518482389

2025-03-06

View on NPI website

EVA GREENWOOD

SVP, FINANCE

4014447914

261QR0404X - Cardiac Rehabilitation Clinic/Center

Yes

+1 401-444-6779

4014446912

+1 401-793-5810

UCC-3 TERMINATION

202531820430

2025-04-03

TerminationSecuredParty

THE MIRIAM HOSPITAL

Debtor(s)

UCC-3 CONTINUATION

202431360090

2024-11-25

Continuation

THE MIRIAM HOSPITAL

Debtor(s)

EMMA PENDLETON BRADLEY HOSPITAL

Debtor(s)

LIFESPAN CORPORATION

Debtor(s)

RHODE ISLAND HOSPITAL

Debtor(s)

UCC-3 CONTINUATION

202431303060

2024-11-08

Continuation

THE MIRIAM HOSPITAL

Debtor(s)

INTUITIVE SURGICAL, INC.

Secured Parties

36C24124P0751

View Award on USAspending website

AWARD

PURCHASE ORDER

$17,850

$17,850

$17,850

Department of Veterans Affairs

2024-08-09

QUALITATIVE SCIENCE METHODS TRAINING PROGRAM

611310: COLLEGES, UNIVERSITIES, AND PROFESSIONAL SCHOOLS

U004: EDUCATION/TRAINING- SCIENTIFIC/MANAGEMENT

36C24123P0862

View Award on USAspending website

AWARD

PURCHASE ORDER

$12,600

$12,600

$12,600

Department of Veterans Affairs

2023-07-01

QSMTP TRAINING

611310: COLLEGES, UNIVERSITIES, AND PROFESSIONAL SCHOOLS

U008: EDUCATION/TRAINING- TRAINING/CURRICULUM DEVELOPMENT

W912LD23F0013

View Award on USAspending website

AWARD

BPA CALL

$13,754.7

$13,754.7

$13,754.7

Department of Defense

2023-04-30

FY22 APRIL MIRIAM LAB CHARGES

621511: MEDICAL LABORATORIES

Q301: MEDICAL- LABORATORY TESTING

NONPROFIT WITH 501C3 IRS STATUS (OTHER THAN AN INSTITUTION OF HIGHER EDUCATION)

2025-05-27

View on USAspending

Department of Health and Human Services

OPTIMIZING A WEIGHT NEUTRAL INTERVENTION TO IMPROVE HEALTH AMONG ADULTS OF HIGHER BODY WEIGHT: A MOST PREPARATION PHASE STUDY - PROJECT SUMMARY OBESITY REMAINS A MAJOR PUBLIC HEALTH CONCERN AND IS A LEADING CONTRIBUTOR TO CARDIOMETABOLIC DISEASE. FRONTLINE TREATMENTS AIM TO DIRECTLY FACILITATE WEIGHT LOSS, BUT OUTCOMES ARE VARIABLE AND DIFFICULT TO SUSTAIN. WEIGHT NEUTRAL APPROACHES ARE GAINING SCIENTIFIC, CLINICAL, AND PUBLIC ATTENTION AS AN ALTERNATIVE PATHWAY TO REDUCING CARDIOMETABOLIC RISK FOR INDIVIDUALS OF HIGHER BODY WEIGHT. THESE PROGRAMS SUPPORT IMPROVED QUALITY OF DIETARY INTAKE AND ENGAGEMENT WITH PHYSICAL ACTIVITY WITHOUT ENCOURAGING WEIGHT LOSS, AND TARGET NOVEL ‘WEIGHT NEUTRAL’ MECHANISMS TO SUPPORT ADHERENCE OVER TIME (E.G., EATING IN RESPONSE TO HUNGER/SATIETY CUES, DISENGAGING FROM RIGID RULES ABOUT FOOD, INCREASED BODY APPRECIATION, COMBATING WEIGHT-RELATED STIGMA, AND PROMOTING PHYSICAL ACTIVITY FOR ENJOYMENT.) DESPITE GROWING INTEREST, EFFICACY FOR WEIGHT NEUTRAL INTERVENTIONS ON CARDIOMETABOLIC HEALTH, ALONG WITH THE GENERALIZABILITY, SCALABILITY, AND SUSTAINABILITY OF TREATMENT EFFECTS IS NOT ESTABLISHED. ADDITIONALLY, THERE IS SIGNIFICANT VARIABILITY IN HOW THE WEIGHT NEUTRAL PROGRAMS ARE DESIGNED (I.E., WHICH WEIGHT NEUTRAL MECHANISMS ARE TARGETED AND HOW), LEAVING IT UNCLEAR WHICH WEIGHT NEUTRAL MECHANISMS MEANINGFULLY CONTRIBUTE TO TREATMENT EFFECTS. THE GOAL OF THIS R03 IS TO USE THE MULTIPHASE OPTIMIZATION STRATEGY (MOST) TO BUILD A CLEARLY DEFINED WEIGHT NEUTRAL INTERVENTION THAT EFFECTIVELY TARGETS THE WEIGHT NEUTRAL MECHANISMS THAT ARE CENTRAL TO THIS THERAPEUTIC APPROACH. CANDIDATE WEIGHT NEUTRAL COMPONENTS WILL INCLUDE THE FOLLOWING EXISTING, EVIDENCE-BASED INTERVENTIONS WITH DEMONSTRATED EFFECTS ON WEIGHT NEUTRAL MECHANISMS; (1) MINDFULNESS-BASED EATING AWARENESS TRAINING (MECHANISMS: TO INCREASE EATING IN RESPONSE TO HUNGER/SATIETY CUES AND REDUCE RIGID DIETARY RESTRAINT), (2) BODY ACCEPTANCE PROGRAM (MECHANISMS: TO IMPROVE BODY APPRECIATION AND REDUCE INTERNALIZED WEIGHT-RELATED BIAS), AND (3) A TAILORED INTERVENTION TO PROMOTE ENJOYMENT OF PHYSICAL ACTIVITY (MECHANISM: ENJOYMENT OF PHYSICAL ACTIVITY). WEIGHT NEUTRAL COMPONENTS WILL COMPLEMENT A CORE INTERVENTION OF STANDARDIZED EDUCATION ON HEALTHY DIET (EMPHASIZING THE MEDITERRANEAN DIET) AND PHYSICAL ACTIVITY GUIDELINES FOR AMERICANS (I.E., AEROBIC ACTIVITY, MUSCLE STRENGTHENING AND SEDENTARY BEHAVIOR). BEFORE EVERY POTENTIAL COMBINATION OF CORE + CANDIDATE WEIGHT NEUTRAL COMPONENTS CAN BE TESTED IN A FULLY POWERED FACTORIAL EXPERIMENT, WE WILL CONDUCT NECESSARY PILOT TESTING IN THIS PREPARATION PHASE STUDY TO ENSURE WE CAN RECRUIT OUR TARGET SAMPLE AND DELIVER THE NOVEL COMBINATIONS OF WEIGHT NEUTRAL COMPONENTS AS INTENDED. TO MAKE STRATEGIC USE OF RESOURCES, A FRACTIONAL FACTORIAL DESIGN WILL BE DEPLOYED. THE CORE INTERVENTION AND CONDITIONS WITH 2+ WEIGHT NEUTRAL CANDIDATE COMPONENTS WILL BE PILOT TESTED. SMALL GROUPS OF RACIALLY/ETHNICALLY DIVERSE ADULTS WITH BMI 25-40KG/M2 (N=50) WILL BE RECRUITED AND RANDOMLY ASSIGNED TO ONE OF THE FIVE TREATMENT COMBINATIONS. THIS PROJECT WILL LEVERAGE THE EXPERTISE THE PI HAS DEVELOPED THROUGH COMPLETION OF HER NIDDK-FUNDED K23 AND ENHANCE HER CAPACITY TO TRANSITION TO INDEPENDENCE BY LAUNCHING A RELATED BUT DISTINCT LINE OF RESEARCH INVESTIGATING THE HEALTH BENEFITS OF WEIGHT NEUTRAL LIFESTYLE INTERVENTIONS FOR INDIVIDUALS OF HIGHER BODY WEIGHT.

$111,750

$0

$0

NONPROFIT WITH 501C3 IRS STATUS (OTHER THAN AN INSTITUTION OF HIGHER EDUCATION)

2025-04-23

View on USAspending

Department of Health and Human Services

COMMUNITY-BASED SUBSTANCE USE TREATMENT AND HIV PREVENTION FOR AFRICAN AMERICAN AND HISPANIC/LATINO MEN WHO HAVE SEX WITH MEN - THE PURPOSE OF OUR PROPOSED PROJECT, COMMUNITY-AND CLINIC-BASED SUBSTANCE USE TREATMENT AND HIV PREVENTION FOR AFRICAN AMERICAN AND HISPANIC/LATINO MEN WHO HAVE SEX WITH MEN IS TO INCREASE STATUS NEUTRAL ACCESS TO AND ENGAGEMENT IN CARE FOR RACIAL AND ETHNIC MEDICALLY UNDERSERVED INDIVIDUALS AT RISK FOR OR LIVING WITH SYNDEMIC CONDITIONS INCLUDING SUBSTANCE USE, MENTAL ILLNESS, HIV, VIRAL HEPATITIS, AND MINORITY STRESS. WITH NEARLY 1.1 MILLION RESIDENTS, RHODE ISLAND HAS ONE OF THE HIGHEST PERCENTAGES OF LGBTQ+ RESIDENTS OF ANY STATE IN THE COUNTRY AND THE MAJORITY RESIDE IN PROVIDENCE, THE CAPITAL CITY. PROVIDENCE IS THE EPICENTER OF SUBSTANCE USE IN RHODE ISLAND AND HAS AMONG THE HIGHEST RATES OF ILLICIT DRUG USE IN THE UNITED STATES. DISPARITIES EXIST BETWEEN THE GENERAL POPULATION AND THE LGBTQ+ COMMUNITY WITH HIGHER RATES AND SEVERITY OF SUBSTANCE USE DISORDERS (SUDS) AND CO-OCCURRING MENTAL HEALTH DISORDERS (CODS) AND LOWER RATES OF ACCESS TO- AND ENGAGEMENT IN- SUBSTANCE USE TREATMENT AMONG RACIAL AND ETHNIC MINORITIES WITH INTERSECTIONAL LGBTQ+ IDENTITIES.DESPITE THE LARGE PERCENTAGE OF UNDERSERVED INDIVIDUALS AND THE KNOWLEDGE OF THESE DISPARITIES, RHODE ISLAND DOES NOT HAVE A DEDICATED TREATMENT PROGRAM THAT ADDRESSES THE IMPORTANT AND UNIQUE NEEDS OF RACIAL AND ETHNIC MEDICALLY UNDERSERVED INDIVIDUALS WITH INTERSECTIONAL LGBTQ+ IDENTITIES WHO SUFFER DISPROPORTIONATE RATES OF SYNDEMIC SUBSTANCE USE, CO-OCCURRING MENTAL HEALTH, MEDICAL, AND SOCIAL CONCERNS. . OUR PROPOSED COMMUNITY- AND CLINIC-BASED PROJECT WILL AIM TO ADDRESS THESE UNMET NEEDS BY PROVIDING AFFIRMING, EVIDENCE-BASED, STATUS NEUTRAL, AND INCLUSIVE OUTREACH AND TREATMENT FOR SUD AND CODS FOR 225 INDIVIDUALS FROM THIS UNDERSERVED COMMUNITY IN RHODE ISLAND. ALIGNED WITH OUR PURPOSE, THE GOALS FOR OUR PROJECT INCLUDE: 1) INCREASING ACCESS TO AND ENGAGEMENT IN CULTURALLY CONGRUENT SUD CARE, 2) DECREASING SUBSTANCE USE AND MENTAL HEALTH SYMPTOMS AMONG CLIENTS WHO ENGAGE IN AND COMPLETE OUR PROJECT SERVICES, 3) INCREASING KNOWLEDGE OF MEDICAL STATUSES OF HIV, VIRAL HEPATITIS, AND STDS, 4) DECREASING HIV INFECTIONS, AND 5) PROMOTING PERSONAL AND ORGANIZATIONAL HEALTH LITERACY TO PREVENT THE PERPETUATION OF MINORITY STRESS, STIGMA, AND DISCRIMINATION WHICH CONTRIBUTE TO SUDS AND CODS. OUR PROGRAM GOALS AND DESIGN ARE DERIVED FROM OUR PROCESS OF CENTERING THE VOICES OF THOSE WITH LIVED EXPERIENCES. WE PLAN TO USE A STATUS NEUTRAL APPROACH BY BRAIDING TOGETHER EXISTING RESOURCES WITH THE NEW PROGRAM SERVICES ACROSS SITES TO DECREASE DISPARITIES IN HEALTH AND ATTEND TO WHOLE PERSON HEALTH CARE. TO MEET THE NEEDS OF OUR COMMUNITY AND ACCOMPLISH OUR GOALS, THE OBJECTIVES OF OUR PROJECT INCLUDE:) SCREENING AT LEAST 800 RACIAL AND ETHNIC MEDICALLY UNDERSERVED INDIVIDUALS WITH INTERSECTIONAL LGBTQ+ IDENTITIES IN COMMUNITY AND CLINIC SETTINGS; 2) PROVIDING COLLABORATIVE, CULTURALLY CONGRUENT, STATUS NEUTRAL MULTIDISCIPLINARY CARE TO 225 INDIVIDUALS TO ADDRESS THE SYNDEMIC OF SUD, CODS, MEDICAL CONCERNS, AND SOCIAL DETERMINANTS OF HEALTH NEEDS, 3) TESTING FOR HIV, VIRAL HEPATITIS, AND STDS IN THE COMMUNITY AND CLINICS, 4) PROVIDING EDUCATION ABOUT UNDETECTABLE = UNTRANSMISSIBLE AND SUPPORT FOR ADHERENCE AND PREP CARE, AND 5) COLLABORATIVELY CREATING AND ENGAGING IN A DYNAMIC EDUCATIONAL CURRICULUM TO SUPPORT DIVERSITY, EQUITY, INCLUSION, BELONGING, AND ANTI-RACISM ACROSS THE THREE PROGRAM SITES.IN SUMMARY, THE PROJECT WILL PROVIDE CRITICAL SERVICES FOR THE SCREENING AND TREATMENT OF SUBSTANCE USE AND OTHER CO-OCCURRING DISORDERS AMONG RACIAL AND ETHNIC UNDERSERVED INDIVIDUALS WITH INTERSECTIONAL LGBTQ+ IDENTITIES IN THE STATE OF RHODE ISLAND WHICH HAS AMONG THE HIGHEST RATES OF ILLICIT DRUG USE IN THE COUNTRY.

$499,002

$0

$0

NONPROFIT WITH 501C3 IRS STATUS (OTHER THAN AN INSTITUTION OF HIGHER EDUCATION)

2025-05-29

View on USAspending

Department of Health and Human Services

MECHANISMS OF MINDFULNESS TRAINING TO REDUCE MATERNAL AND INFANT CARDIOVASCULAR DISEASE RISK - ABSTRACT HYPERTENSIVE DISORDERS OF PREGNANCY ARE THE MOST COMMON MEDICAL CONDITION AFFECTING PREGNANCY AND A LEADING CAUSE OF MATERNAL MORBIDITY AND MORTALITY IN THE UNITES STATES. FIFTY PERCENT OF WOMEN WITH PRENATAL HYPERTENSIVE DISORDERS WILL CONTINUE TO EXPERIENCE HYPERTENSION IN THE POSTPARTUM PERIOD. MORE THAN HALF OF ALL PREGNANCY-RELATED DEATHS OCCUR IN THE POSTPARTUM PERIOD, AND OVER 30% OF MATERNAL DEATHS ARE COMPLICATED BY HYPERTENSIVE DISORDERS. CONSEQUENCES OF HYPERTENSIVE DISORDERS EXTEND WELL PAST THE PERINATAL PERIOD; WOMEN WITH PRENATAL HYPERTENSIVE DISORDERS ARE TWICE AS LIKELY TO DEVELOP HEART DISEASE IN THEIR LIFETIME, AND OFFSPRING EXPOSED TO HYPERTENSIVE DISORDERS IN UTERO FACE SIGNIFICANT LIFETIME CARDIOVASCULAR DISEASE RISK. THEREFORE, PREVENTION OF PRENATAL HYPERTENSIVE DISORDERS IS CRITICAL TO REDUCING RISK FOR POSTPARTUM OBSTETRIC COMPLICATIONS AND LIFELONG CARDIOVASCULAR DISEASE. MINDFULNESS-BASED INTERVENTIONS HOLD SIGNIFICANT PROMISE AS A NON- PHARMACOLOGICAL INTERVENTION TO PREVENT THESE DISORDERS AS MINDFULNESS-BASED INTERVENTIONS REDUCE BLOOD PRESSURE IN ADULTS WITH HYPERTENSION AND PREHYPERTENSION, AND RESULTS FROM OUR PILOT RCT INDICATING THAT PRENATAL MINDFULNESS TRAINING WAS ASSOCIATED WITH REDUCED BLOOD PRESSURE AND RISK FOR HYPERTENSIVE DISORDERS IN AT-RISK WOMEN. NOW, OUR TEAM IS CONDUCTING A 5-YEAR RCT INVESTIGATING THE DAILY MECHANISMS OF PRENATAL MINDFULNESS TRAINING ON PRENATAL MARKERS OF CARDIOVASCULAR RISK (R01HL157288). TO DATE, WE HAVE RECRUITED A RACIALLY AND ETHNICALLY DIVERSE SAMPLE OF WOMEN AT RISK FOR HYPERTENSIVE DISORDERS OF PREGNANCY, WITH >90% PARTICIPANT RETENTION, AND 89% OF PARTICIPANTS WHO COMPLETED THE PARENT STUDY REPORTED INTEREST IN PARTICIPATING IN THE PROPOSED ANCILLARY STUDY. HOWEVER, THE MOST SEVERE AND FATAL CARDIOVASCULAR COMPLICATIONS OCCUR IN THE POSTPARTUM PERIOD, AND IT IS NOT YET KNOWN WHETHER THE CARDIOVASCULAR BENEFITS OF PRENATAL MINDFULNESS TRAINING EXTEND INTO THE POSTPARTUM PERIOD. THUS, IN RESPONSE TO THE NOTICE OF SPECIAL INTEREST (NOSI): “HEART, LUNG, BLOOD AND SLEEP FOCUSED ANCILLARY STUDIES TO ONGOING CLINICAL STUDIES,” WE PROPOSE TO TEST THE LONG-TERM EFFECTS OF PRENATAL MINDFULNESS TRAINING ON POSTPARTUM MECHANISMS OF RISK FOR MATERNAL AND INFANT CARDIOVASCULAR DISEASE. THE PROPOSED ANCILLARY STUDY WILL FOLLOW N=130 PARTICIPANTS AND INFANTS THAT ARE ENROLLED IN THE PARENT RCT ACROSS THE FIRST POSTPARTUM YEAR. AT 4-, 6-, AND 12-MONTHS POSTPARTUM, WE WILL MEASURE EFFECTS OF PRENATAL MINDFULNESS TRAINING ON: 1) POSTPARTUM MATERNAL CARDIOVASCULAR DISEASE BIOMARKERS, 2) POSTPARTUM PHYSIOLOGICAL AND PSYCHOLOGICAL RESPONSES TO ECOLOGICALLY VALID DAILY EXPERIENCES, AND 3) INFANT GROWTH TRAJECTORIES THAT CONFER RISK FOR LIFETIME CVD. RESULTS WILL HAVE A SIGNIFICANT IMPACT ON THE FIELD BY IDENTIFYING MODIFIABLE MECHANISMS IN THE PRE AND POSTNATAL PERIODS TO REDUCE RATES OF HYPERTENSIVE DISORDERS AND DECREASE LIFELONG BURDEN OF CVD IN WOMEN AND THEIR OFFSPRING. CONSISTENT WITH NHLBI’S OBJECTIVES, RESULTS FROM THIS STUDY WILL HELP TO DEVELOP AND OPTIMIZE NOVEL THERAPEUTIC STRATEGIES TO PREVENT HEART, LUNG, AND BLOOD DISEASES IN WOMEN AND INFANTS.

$1,228,181

$0

$0

NONPROFIT WITH 501C3 IRS STATUS (OTHER THAN AN INSTITUTION OF HIGHER EDUCATION)

2025-05-27

View on USAspending

Department of Health and Human Services

MICRORANDOMIZED TRIAL TO OPTIMIZE USE OF BURDEN-REDUCING SELF-MONITORING APPROACHES IN BEHAVIORAL OBESITY TREATMENT - PROJECT SUMMARY ABSTRACT SELF-MONITORING (SM) IS AN ESSENTIAL COMPONENT GOLD-STANDARD BEHAVIORAL TREATMENT OF OBESITY (BOT) – THE MOST PREVALENT CAUSE OF MORBIDITY AND MORTALITY IN THE US. ADHERENCE TO DIETARY SELF-MONITORING IS ONE OF THE STRONGEST CONSISTENT PREDICTORS OF TREATMENT OUTCOMES. HOWEVER, ADHERENCE TO DIETARY SM IS GENERALLY POOR DUE TO THE BURDEN OF THE GOLD-STANDARD SM APPROACH (I.E., DETAILED TRACKING OF ALL FOOD & DRINK CONSUMED). DISCONTINUATION OF DIETARY SM IS DIRECTLY CORRELATED WITH AN END TO WEIGHT LOSS, AND IT INCREASES RISK OF WEIGHT REGAIN. IMPROVING ADHERENCE TO DIETARY SM IS THUS ONE OF THE MOST CRITICAL STRATEGIES FOR TREATING OBESITY. ALTERNATIVE SM APPROACHES HAVE BEEN DEVELOPED TO REDUCE BURDEN OF DIETARY SM AND THEREBY IMPROVE ADHERENCE. PRIOR WORK SHOWS THAT THESE SM ALTERNATIVES HAVE THE POTENTIAL TO SUSTAIN SM ADHERENCE AND IMPROVE WEIGHT LOSS IN BOT. HOWEVER, THERE IS NO SCIENTIFIC CONSENSUS IN HOW OR WHEN TO APPLY SM ALTERNATIVES FOR MAXIMUM BENEFIT. TO ADDRESS THIS CRITICAL GAP, WE WILL CONDUCT A MICRO-RANDOMIZED TRIAL (MRT) TO DETERMINE WHICH SM STRATEGY TO APPLY FOR WHOM, AND AT WHAT POINT DURING BOT, TO MAXIMIZE SM ADHERENCE AND WEIGHT LOSS. MRT INVOLVES REPEATED RANDOMIZATIONS AT SPECIFIC DECISION POINTS, WHICH ENABLES DATA-DRIVEN OPTIMIZATION OF THE COMPOSITION, TAILORING, AND TIMING OF BEHAVIORAL INTERVENTIONS. BY USING MRT TO COMPARE SM STRATEGIES OVER TIME WITHIN INDIVIDUALS AND EVALUATING FACTORS THAT INFLUENCE THEIR EFFICACY, WE CAN ENABLE BROADLY-APPLICABLE SM RECOMMENDATIONS TO IMPROVE BOT. WE CAN THEN USE THESE DATA TO DEVELOP ALGORITHMS THAT CAN REPEATEDLY AND AUTOMATICALLY ADAPT SM RECOMMENDATIONS BASED ON EACH INDIVIDUAL’S PERFORMANCE AND NEEDS. OUR MRT WILL TEST THE EFFECTS OF GOLD- STANDARD DIETARY SM AND 4 SM ALTERNATIVES ON SM ADHERENCE AND WEIGHT LOSS DURING A 24-WEEK BOT. A DIVERSE SAMPLE OF ADULTS WITH OVERWEIGHT/OBESITY WILL RECEIVE OUR ESTABLISHED, ONLINE BOT FOR 24 WEEKS. AT PROGRAM START, AND EVERY 2 WEEKS THEREAFTER, PARTICIPANTS WILL BE RANDOMIZED TO ONE OF FIVE SM APPROACHES, FOR A TOTAL OF 12 INDEPENDENT RANDOMIZATIONS PER PERSON. THE SM APPROACHES TO BE TESTED ARE: GOLD-STANDARD FULL DIETARY SM OF ALL FOODS/DRINKS AND THEIR KCALS; REDUCED-FREQUENCY FULL DIETARY SM (3 D/WK); SM OF DIETARY LAPSES ONLY; SMARTWATCH-BASED MONITORING OF ENERGY INTAKE; AND SM OF BODY WEIGHT ONLY VIA SMART SCALE. DATA FROM THIS MRT WILL HAVE TREMENDOUS SCIENTIFIC AND PRACTICAL IMPACTS; WE WILL EVALUATE THE EFFICACY OF ALTERNATIVE SM APPROACHES ON SM ADHERENCE AND WEIGHT LOSS AS WELL AS HOW EACH STRATEGY WORKS ACROSS INDIVIDUAL DIFFERENCES (E.G., SEX), SOCIAL DETERMINANTS OF HEALTH (E.G., FINANCIAL RESOURCE STRAIN), AND TIME-VARYING TREATMENT (E.G., WEEK OF TREATMENT) FACTORS. WE WILL USE REINFORCEMENT LEARNING, A MACHINE LEARNING APPROACH, TO CREATE AN ADAPTIVE SM-SELECTION ALGORITHM THAT AUTOMATICALLY DETERMINES THE SM APPROACH MOST LIKELY TO MAXIMIZE OUTCOMES FOR A GIVEN INDIVIDUAL THROUGHOUT TREATMENT. THIS PROPOSAL WILL ACHIEVE BOTH SCIENTIFIC AND PRACTICAL PUBLIC HEALTH BENEFIT BY USING A SOPHISTICATED DATA-DRIVEN APPROACH TO UNDERSTAND THE FACTORS THAT INFLUENCE SM ADHERENCE DURING BEHAVIORAL OBESITY TREATMENT, AND PROVIDE AN ALGORITHM TO OPTIMIZE SM IN FUTURE CLINICAL AND RESEARCH APPLICATIONS.

$1,108,930

$0

$0

NONPROFIT WITH 501C3 IRS STATUS (OTHER THAN AN INSTITUTION OF HIGHER EDUCATION)

2025-03-19

View on USAspending

Department of Health and Human Services

DIFFERENTIAL THROMBOGENESIS EFFECTS OF EPA AND DHA MEDIATED BY HDL - PROJECT SUMMARY EPIDEMIOLOGICAL STUDIES SUGGEST THAT THE CONSUMPTION OF OMEGA-3 POLYUNSATURATED FATTY ACIDS (N-3 PUFAS) DERIVED FROM FISH OIL, MAINLY CONSISTING OF EICOSAPENTAENOIC ACID (EPA; 20:5 N-3) AND DOCOSAHEXAENOIC ACID (DHA; 22:6 N-3), IS ASSOCIATED WITH LOWER CARDIOVASCULAR RISK. HOWEVER, INTERVENTIONAL CLINICAL TRIALS AIMED AT REDUCING CARDIOVASCULAR INCIDENTS BY SUPPLEMENTATION WITH N-3 PUFAS HAVE YIELDED INCONSISTENT RESULTS. THE MECHANISMS RESPONSIBLE FOR THE BENEFIT OF N-3 PUFAS ON CARDIOVASCULAR RISK ARE STILL NOT COMPLETELY UNDERSTOOD. MOUNTING EVIDENCE SUGGESTS THAT IN ADDITION TO LOWERING TRIGLYCERIDES, THE TRIGLYCERIDE-INDEPENDENT EFFECTS OF N-3 PUFAS ALSO CONTRIBUTE TO THEIR CARDIOVASCULAR BENEFITS. IT IS LIKELY THAT DIFFERENTIAL EFFECTS OF EPA AND DHA ALSO CONTRIBUTE TO THE INCONSISTENT CLINICAL RESULTS. A HEAD-TO-HEAD COMPARISON OF THE BIOLOGICAL EFFECTS OF EPA AND DHA IN A RELEVANT POPULATION IS URGENTLY REQUIRED. BASED ON OUR PRELIMINARY DATA, WE HYPOTHESIZE THAT EPA AND DHA HAVE DIFFERENTIAL EFFECTS ON THROMBOGENESIS IN PATIENTS WITH ATHEROGENIC DYSLIPIDEMIA THAT ARE MEDIATED BY THE MODIFICATION OF HDL PARTICLE FUNCTION. WE PROPOSE A PROOF-OF-CONCEPT CLINICAL STUDY COMPARING THE BIOLOGICAL EFFECTS, PARTICULARLY THE THROMBOGENESIS AND ANTIPLATELET EFFECTS, OF AN ADEQUATE DOSE OF EPA AND DHA HEAD-TO- HEAD IN ATHEROGENIC DYSLIPIDEMIA SUBJECTS. WE WILL ALSO EXAMINE THE MECHANISM OF HOW HDL PARTICLES MEDIATE THESE ANTITHROMBOTIC EFFECTS. SPECIFIC AIM1: TO TEST THE HYPOTHESIS THAT EPA AND DHA DIFFERENTIALLY AFFECT PLATELET ACTIVATION AND THROMBOSIS IN VIVO IN SUBJECTS WITH ATHEROGENIC DYSLIPIDEMIA. HUMAN SUBJECTS WITH ATHEROGENIC DYSLIPIDEMIA WILL BE RANDOMIZED TO DIETARY SUPPLEMENTATION WITH FOUR GRAMS OF EITHER EPA OR DHA N-3 PUFAS IN A SINGLE-BLINDED FASHION FOR EIGHT WEEKS. AT BASELINE AND AFTER THE SUPPLEMENTATION, VARIOUS MARKERS OF THROMBOGENESIS WILL BE ASSESSED. SPECIFIC AIM 2: TO TEST THE HYPOTHESIS THAT THE EFFECTS OF N-3 PUFAS ON PLATELETS ARE MEDIATED BY THE MODULATION OF HDL PARTICLE FUNCTION. AT BASELINE AND POST N-3 PUFA SUPPLEMENTATION, HDL PARTICLE COMPOSITION AND HDL FUNCTIONS WILL BE ANALYZED, RESPECTIVELY. WE WILL FURTHER TEST OUR HYPOTHESIS MECHANISTICALLY IN AN HDL-DEFICIENT MOUSE MODEL. HDL-DEPENDENT BIOACTIVE LIPID PRODUCTION WILL BE CHARACTERIZED IN BOTH HUMAN AND MOUSE STUDIES. THESE STUDIES WILL PROVIDE INSIGHT INTO A NEW PARADIGM OF UNDERSTANDING THE PUZZLING CLINICAL EVIDENCE OF N-3 PUFAS AND MAY ULTIMATELY LEAD TO THE DEVELOPMENT OF NOVEL THERAPIES TO COMBAT CARDIOMETABOLIC RISK.

$1,094,422

$0

$0

2022-04-28

Complaint

164 SUMMIT AVE., PROVIDENCE, RI, 02906

Safety

Partial

2010-04-14

Complaint

164 SUMMIT AVENUE, PROVIDENCE, RI, 02906

Health

Partial

View Inspection data on OSHA website

1998-03-18

Complaint

164 SUMMIT AVE., PROVIDENCE, RI, 02906

Health

Partial

View Inspection data on OSHA website

1992-08-14

Referral

164 SUMMIT AVE., PROVIDENCE, RI, 02906

Safety

Partial

View Inspection data on OSHA website

1992-07-27

Complaint

164 SUMMIT AVE., PROVIDENCE, RI, 02906

Health

Complete

View Inspection data on OSHA website

05-0258905

Government Instrumentality, Title-Holding Corporation, Charitable Organization, Agricultural Organization, Board of Trade, Pleasure, Recreational, or Social Club, Fraternal Beneficiary Society, Order or Association, Voluntary Employees' Beneficiary Association (Non-Govt. Emps.), Domestic Fraternal Societies and Associations, Teachers Retirement Fund Assoc., Benevolent Life Insurance Assoc., Burial Association, Credit Union, Mutual Insurance Company or Assoc. Other Than Life or Marine, Corp. Financing Crop Operations, Supplemental Unemployment Compensation Trust or Plan, Employee Funded Pension Trust (Created Before 6/25/59), Post or Organization of War Veterans, Legal Service Organization, Black Lung Trust, Multiemployer Pension Plan, Veterans Assoc. Formed Prior to 1880, Trust Described in Sect. 4049 of ERISA, Title Holding Co. for Pensions, etc., State-Sponsored High Risk Health Insurance Organizations, State-Sponsored Workers' Compensation Reinsurance, ACA 1322 Qualified Nonprofit Health Insurance Issuers, Apostolic and Religious Org. (501(d)), Cooperative Hospital Service Organization (501(e)), Cooperative Service Organization of Operating Educational Organization (501(f)), Child Care Organization (501(k)), Charitable Risk Pool, Qualified State-Sponsored Tuition Program, 4947(a)(1) - Private Foundation (Form 990PF Filer)

1935-01

Type of organization and use of contribution: A public charity. Deductibility Limitation: 50% (60% for cash contributions)

2022-09-07

Terminated

no monetary award

Both plaintiff and defendant demand jury

Medical Malpractice

THE MIRIAM HOSPITAL

Defendant

LEDERBERG

Plaintiff

LEDERBERG LLC

Plaintiff

2019-02-12

Terminated

no monetary award

Plaintiff demands jury

Americans with Disabilities Act - Employment

TRIMBLE

Plaintiff

THE MIRIAM HOSPITAL

Defendant

Trimble Inc.

Plaintiff

2014-07-15

Terminated

no monetary award

Neither plaintiff nor defendant demands jury

Civil Rights Employment

FERGUSON

Plaintiff

THE MIRIAM HOSPITAL

Defendant